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Micoderm Cream is prescribed for various fungal skin infections (dermatomycoses) including:
- Athlete’s foot (Tinea pedis)
- Ringworm of the body (Tinea corporis)
- Fungal infections of the hand (Tinea manuum)
- Jock itch (Tinea cruris) caused by Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii, Epidermophyton floccosum
- Candidiasis (yeast infections)
- Tinea versicolor
- Inflamed skin folds (intertrigo)
- Perianal fungal infections
- Angular stomatitis (cheilitis)
- Balanoposthitis
- Otitis externa (outer ear infections)
Micoderm Cream also provides rapid relief from itching (pruritus) often associated with fungal infections.
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✅ Description:
Pharmacodynamics:
Miconazole exhibits potent antifungal action against common dermatophytes and yeasts and also possesses antibacterial activity against some gram-positive organisms. It works by inhibiting an essential step in the production of ergosterol, a key component of the fungal cell membrane. The absence of ergosterol disrupts membrane integrity, leading to leakage of essential intracellular contents and cell death.
Pharmacokinetics:
Orally, miconazole has limited absorption (about 25–30%). When administered as an oral gel, it is partly absorbed and binds strongly to plasma proteins, mainly serum albumin and red blood cells. It undergoes hepatic metabolism, with less than 1% excreted unchanged in urine. The average elimination half-life ranges from 20 to 25 hours, with similar clearance in patients with kidney impairment.
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✔️ Dosage & Administration
Miconazole Cream
- Apply to affected areas twice daily (morning and evening) for tinea infections and cutaneous candidiasis, and once daily for tinea versicolor.
- In skin fold areas, apply sparingly and massage well to avoid skin softening (maceration).
- Symptom relief usually begins within 2–3 days, and infections typically clear within 2–5 weeks.
- To prevent recurrence, continue treatment 10 days after symptom resolution.
- Treat Candida, tinea corporis, and cruris for 2 weeks, and tinea pedis for 4 weeks.
✔️ Side Effects
Rare: Nausea, vomiting, diarrhea, especially with long-term use.
Occasionally, Allergic skin reactions.
✔️ Drug Interactions
Avoid combining with terfenadine, astemizole, or cisapride, as miconazole may inhibit their metabolism and elevate toxicity risk.
May also increase blood levels of phenytoin and cyclosporine, necessitating monitoring.
✔️ Contraindications
Do not use in individuals with known allergy or hypersensitivity to miconazole or any component of the formulation.
✔️ Use in Pregnancy & Lactation
- Safety during pregnancy has not been fully established—use only if needed and prescribed.
- Exercise caution during breastfeeding, as many medications may be excreted in breast milk.
✔️ Precautions & Warnings
- When co-administered with anticoagulants, monitor bleeding risk and adjust dosage as needed.
- Monitor levels of phenytoin and cyclosporine when used concurrently.
- In infants and small children, ensure the gel does not block the throat.
✔️ Storage
Store in a cool, dry place away from heat and light. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
